NFL DFS Thursday Night Football picks: Top 49ers vs. Seahawks fantasy lineup advice for DraftKings, FanDuel

The Week 15 NFL schedule opens with Brock Purdy and the red-hot San Francisco 49ers visiting Geno Smith and the Seattle Seahawks in a NFC West rivalry game on Thursday Night Football. The 49ers have won six straight games, but will be without dynamic wide receiver Deebo Samuel, which should be considered when building your NFL DFS lineups and NFL DFS stacks for Seahawks vs. 49ers. With Samuel unavailable, should Purdy be downgraded in your TNF Showdown NFL DFS strategy? Or would it make sense to look at the running backs, tight ends, wide receivers, or a D/ST in the TNF NFL DFS player pool? Christian McCaffrey, Brandon Aiyuk, George Kittle, Kenneth Walker III, Tyler Lockett, and DK Metcalf all project to be impact classic and showdown NFL DFS picks for Thursday Night Football. 

Before making any Thursday NFL DFS picks for 49ers vs. Seahawks on sites like DraftKings and FanDuel of your own, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor. 

Kaylor is an NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3, 6-106-1, 7-92-1), Amari Cooper (7-101-1, 5-131-1), Nick Chubb (23-113-1, 23-101-2), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4, 10-106), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Derrick Henry (132-2), Jimmy Garoppolo (228-4), and Michael Pittman (7-61-1). Anyone who has followed his picks is way up.

Now, Kaylor has turned his attention to Seahawks vs. 49ers on Thursday Night Football Week 15 and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Seahawks vs. 49ers on TNF

One of Kaylor’s top DFS picks for the Seattle vs. San Francisco showdown slate on TNF is 49ers running back Christian McCaffrey. The two-time All-Pro Week 15 with a chance to eclipse 2,000 total offensive yards for the second time in his NFL career. McCaffrey has 174 carries for 819 yards and five touchdowns on the ground and 68 receptions for 593 yards and four touchdowns through the air. With Seattle’s ongoing defensive struggles, Kaylor is expecting the former Stanford star to thrive on Thursday Night Football. 

“Christian McCaffrey is a must-start player in most Showdown slates on both FanDuel and DraftKings, but I am particularly high on him in Week 15 against the Seahawks. San Francisco will be without wide receiver Deebo Samuel, which alone should open up a few more touches for McCaffrey. Couple that with Seattle ranking second to last in the league rushing yards allowed per game (160.5) and you have the makings of a monster NFL DFS performance for McCaffrey on TNF. I am projecting around 20 touches for 125+ total yards and a touchdown for McCaffrey on Thursday night,” Kaylor told SportsLine. You can see the rest of Kaylor’s NFL DFS picks here.

How to make NFL DFS lineups for 49ers vs. Seahawks on TNF

Kaylor is also targeting another undervalued option that could explode for huge numbers for Thursday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor’s TNF DFS picks, at SportsLine. 

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Thursday Night Football? And which under-the-radar DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.